مقایسه تاثیر گیاه شیرین‌بیان با آنتی‌بیوتیک‌های نالیدیکسیک اسید و نیتروفورانتوئین بر باکتری‌های جدا شده از بیماران مبتلا به سنگ‌ها وعفونت ادراری

Abstract Background: Although current medicine has some advantages compared with traditional medicine, one of its important problems is overuse of chemical drugs that leads to drug resistance and side effects. According to antibacterial effects of Glycyrrhiza glabra extracts, this study was conducted to Compare effects of Glycyrrhiza glabra and nalidixic acid and nitrofurantoin on isolated bacteria from urinary tract infections and stones Methods: This is an experimental study was done on 100 patients with urinary tract infections and stones. Glycyrrhiza glabra extract was taken from risome of 3- or 4- year herb by method of perculation with methanol 85% solvent. Solvent was vaporized by rotary and lyophilized. Antibacterial effects of extract, nitrofurantoin and nalidixic acid were evaluated by two methods of disc diffusion and MIC. Statistical analysis was performed by ANOVA and paired t- test. Results: In disc diffusion, 100% of Streptococcus and MRSA and 33% of E.coli were susceptible to Glycyrrhiza glabra extract. In MIC, Streptococcus, MRSA, Enterococcus fecalis in 1:128 dilution, and E.coli in 1:64 dilution of Glycyrrhiza glabra extract were susceptible. Klebsiella, Serattia, and Entrococcus facium were resistant. Diameter of no growth of bacteria among gram positive and negative bacteria were significantly different in Glycyrrhiza glabra extract and nitrofurantoin groups (p<0.05), and was non significantly different in nalidixic acid group (p=0.9). Conclusion: It seems that Glycyrrhiza glabra extract with antibiotics can be useful in the treatment of urinary tract infections. Keywords: Glycyrrhiza glabra, Isolated bacteria, Antibacterial, Gram Positive bacteria, Antibiotic resistance.